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However, pharmacological inhibition of autophagy has been found to enhance galangin-induced apoptosis and pyroptosis in human GBM cells, which proposes an effective therapeutic approach for GBM by a combination of galangin and an autophagy inhibitor [202]

IKK is overexpressed in tumors, including pancreatic, breast, ovarian, lung, myeloma, rectal, and leukemia cancers, and IKK-mediated NF-B pathway is a key signal transduction pathway involved in the occurrence and development of tumors [39]

CD8 + T cells with tissue-resident memory (TRM) signature have been recently highlighted in the contribution to tissue fibrosis in aged mice (93)

Exercise alone or in combination has been reported increasingly in recent years for its effect in preventing or treating CIPN however, the evidence stems from studies in adult patients

Auinger, A
