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The directionality of the ANLS hypothesis (i.e., lactate from astrocytes to neurons), has been covered in many reviews
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Science 348 , 11471151 (2015)

Collagen is essential for maintaining skin structure and firmness, and its production naturally declines with age
Midlife is not a slow decline

Understanding the mechanisms driving oxidative stress and inflammation in critically ill and trauma patients will be critical for developing targeted therapies that minimize complications, preserve organ function, and improve survival outcomes in this high-risk population
