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In EP, but not in controls, smaller hippocampal volume was associated with high GPx activity

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At 52 weeks of continuous daily use, 34% of patients still had IGF-1 levels more than 2 standard deviations above their starting point meaning the downstream IGF-1 signal was still very much working a full year in

We also investigated the impact of glutamine shortage in a short-term setting

Further enzymatic investigation showed that the wild-type enzyme exhibited a robust DTNB reductase activity, and SjTGR U597C with a mutation on the critical selenol group had no detectable redox catalytic activity under the same assay conditions (Fig 1L), demonstrating that the selenol group is essential for SjTGR enzymatic function