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Interestingly, overexpression of the c-KIT tyrosine kinase, a key regulator of melanocytes, has been described in a great number of mucosal melanoma cases (from 39 to 88% depending on the study) and could be a marker or even a target for KIT inhibitors for the treatment of metastatic mucosal melanomas [3, 31]
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Variant amino acids in different domains of the human melanocortin 1 receptor impair cell surface expression
10.3390/nu11061322
