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Description
The primary efficacy outcome measure was overall survival

Nociceptive pain, arising from actual or imminent tissue injury, encompasses well-defined somatic pain or diffuse visceral discomfort accompanied by autonomic symptoms such as nausea and diaphoresis

Their reasoning

Evidence suggests that an imbalance between tonic and phasic dopamine signaling, characterized by reduced baseline activity but exaggerated transient reward responses, leads to abnormally strong reward reinforcement effects and manifests clinically as impulsivity and distractibility (144)

10.1155/2012/645460 10.1155/2012/645460 [DOI] [PMC free article] [PubMed] [Google Scholar] Diwadkar-Navsariwala V, Prins GS, Swanson SM (2006) Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model
