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Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro

Interestingly, in this case, FAK inhibition only allowed melanoma cells with genetic resistance mechanisms to survive treatment, leading to more predictable resistance mechanisms and the absence of multi-drug resistance 43

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Experimental studies have demonstrated that the astragaloside-related enhancement of cell and organelle autophagy plays a pivotal role in the degradation and new synthesis of collagen I [26]

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