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The prominent histological and molecular features of tendinopathy include disorganization of collagen fibres, an increase in the microvasculature and sensory nerve innervation, dysregulated extracellular matrix homeostasis, increased immune cells and inflammatory mediators, and enhanced cellular apoptosis

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Among them, SIRT1 is the most studied for its role in fat metabolism, muscle preservation, and mitochondrial health

In order to achieve the above object, the present invention adopts the following technical solutions: a synthetic method of Cagrilintide comprises the following steps: selecting 7-8 th amino acid of a Cagrilintide sequence as a pseudo-pro dipeptide Fmoc-Ala-Thr (pro-me-me) -OH, taking 10-11 th amino acid of the Cagrilintide sequence as a pseudo-pro dipeptide Fmoc-Ala-Thr (pro-me-me) -OH, and taking 21-22 th amino acid of the Cagrilintide sequence as a pseudo-pro dipeptide Fmoc-Ser-Ser (pro-me-me) -OH