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This phenomenon is often explained by the Glutathione Depletion-Methylation Cycle Block (GD-MCB) hypothesis , originally proposed to explain how Long COVID can trigger ME/CFS

Apart from the free polysaccharide of hyaluronan, they are typically sulfated and covalently attached to their respective core proteins to form a larger complex known as the proteoglycan

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Wilsons disease: cranial MRI observations and clinical correlation