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10.1016/j.tibs.2003.09.001 [DOI] [PubMed] [Google Scholar] Birchmeier C., Birchmeier W., Gherardi E., Vande Woude G

The pathological features of PD is the selective loss of dopamine producing neurons within the substantia nigra, resulting in a significant decline in striatal dopamine levels 3

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However, -syn-induced astrocytic mitochondrial dysfunction disrupts this detoxification pathway, leading to toxic lipid reaccumulation in neurons and establishing a PD-accelerating feedback loop (166,167)