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Combining erastin with vitamin C has been shown to increase intracellular ferrous iron levels via the AMPK/Nrf2/HMOX1 axis, resensitizing PDAC cells to ferroptosis and presenting a novel therapeutic approach [151]

Such a synergic effect with NAC may be of value in the use of central nervous systemdirected -lactam antibiotics in clinical studies

10.1016/j.freeradbiomed.2016.08.001 Free Radic