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To validate the direct activation of the CENPT promoter by ATF2, we constructed luciferase reporter vectors containing different binding sites

Oxidative stress in AD is also linked to mitochondrial dysfunction, inflammation, and hypoxia, and these processes culminate in vicious cycles that contribute to neurodegeneration (Bonda et al., The reverse transsulfuration pathway plays a pivotal role in the maintenance of redox balance in cells

Clinical trials conducted on patients with congenital retinal diseases such as Leber hereditary optic neuropathy have shown promising results with direct gene medical application in the treatment of optic neuropathy [124,125]

Machado M, Peixoto D, Santos P, Ricardo A, Duarte I, Carvalho I, Arago C, Azeredo R, Costas B