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Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association

Hecker J, Layton R, Parker RW (2025) Adverse effects of excessive folic acid consumption and its implications for individuals with the methylenetetrahydrofolate reductase C677T genotype

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The most common indicators, seen in children with a developmental age of at least 9 months, include: overly affectionate or a lack of inhibition when meeting new adults willingness to leave a safe place with a stranger eagerness to engage with adults or strangers socially, physically or conversationally in unusual ways lack of concern or checking in with their typical caregiver before interacting or leaving with a stranger Clearly, these signs can be very frightening to a parent, whose primary concern is to keep their children safe and secure, primarily by their side

Larger effects were observed in Mischley et al