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We observed clinically relevant improvements in lung function shortly after drug administration, which further improved for at least 45 min

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TM2, in particular, adopts a conformation in the orforglipron-bound structure that would be difficult to predict computationally, highlighting the receptor's conformational flexibility and the inherent limitations of structure-based drug design for class B GPCRs

2.0.1 (Liao, Smyth, and Shi 2014) was used to count the number of reads overlapping with each gene as specified in the genome annotation (Homo_sapiens