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Figure 1 2 Pathogenesis of RA RA is an inflammatory disease caused by multi-cells communication and interaction by cytokines, which result in a variety of pathological reactions ( The cell-cell contact or cytokine signals from antigen-presenting cells (APCs) (especially Dendritic cells, DC) induced the conversion of T cells, B cells, synovial fibroblasts, osteoclasts and osteoblasts

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It has been suggested that G6PD deficiency and thalassemia also protect against malaria by increasing the clearance and decreasing the adherence of infected red cells, possibly by raising levels of oxidant stress and causing membrane damage in the parasite-bearing cells that leads to their rapid removal from the bloodstream

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