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Although it is widely known that TMAO stabilizes the folded state of proteins, the mechanism by which TMAO interacts with proteins remains speculative
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33 Isabel Tristn analyzed 80 serum and urine samples from COVID-19 patients (34 in intensive care and 46 hospitalized) and 32 healthy controls, identifying various metabolites, including TMAO, that could serve as biomarkers for the diagnosis, prognosis and severity assessment of COVID-19
