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The use of targeted nanocarriers solves the problems of both insufficient brain penetration of hydrophilic therapeutic molecules and high treatment doses inducing side-effects at the periphery [21, 26]

Mast cell activation and degranulation are followed by immune activation, for instance, the recognition of LPS by toll-like receptors or by IgE receptor activation

Kathleen Aicher 2

An aliquot of the supernatant was then injected into an Agilent 6460 QQQ LCMS/MS for targeted singlereaction monitoring (SRM)based quantitation of metabolites
