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313 Cuproptosis evasion in tumor progression and therapeutic resistance Despite the presence of a cuproptosis-mediated tumor suppression mechanism, tumors can still arise and progress uncontrollably, suggesting the existence of evasion mechanisms against cuproptosis in cancer cells (Fig

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Circumstantial evidence for this hypothesis comes from one cohort study in which the combination of low B12 and high folate status was associated with lower serum holotranscobalamin concentrations than when B12 was low but folate was not elevated (81)

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