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These conflicting results may potentially be explained by differences in model systems used (CRC-bearing mice vs human healthy-donor-derived CD8 T cells) and the dosing and concentration of butyrate (bacterial supernatant vs purified metabolite)

Clinical evaluation should focus on the temporal relationship between ED onset and DM duration, long-term glycaemic control, the presence of microvascular complications, neuropathic symptoms, and associated lower urinary tract complaints

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In the three trials that included a total of 40 participants with exercise-induced bronchoconstriction, vitamin C administration before exercise (a 0.5-g dose on two subsequent days in one trial, a single dose of 2 g in the second trial, and 1.5 g daily for two weeks in the third trial) significantly reduced the exercise-induced decline in FEV 1