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Activation of the SIRT1/Nrf2 pathway, such as by alpha lipoic acid, can modulate iron metabolism and mitigate ferroptosis by up-regulating ferritin and ferritin heavy chain 1 (FTH1), and down-regulating the iron import protein divalent metal transporter 1 (DMT1) (Zheng et al., 2023)

In: Gvozdjkov A, Cornlissen G, Singh RB (eds), Recent advances in mitochondrial diseases and coenzyme Q 10 , NOVA Sciences, USA, pp 7179 Editor information Editors and Affiliations Rights and permissions Copyright information 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Gvozdjkov, A

In colorectal cancer, NSUN2 enhances the stability of PHGDH mRNA through m5C methylation, thereby activating the SSP, increasing the intracellular NADH/NAD + and NADPH/NADP + ratios, reducing ROS levels and apoptosis, and promoting tumor cell survival and proliferation (105)