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Drug Metabolism Personalized Ther

Numerous clinical studies have demonstrated that IGF-1/IGF-1R mutations are associated with mental retardation and microcephaly [34, 35] (Table 2)

7A, 7B, 8)

Another important ABC transporter, BCRP, encoded by the ABCG2 on chromosome 4, has been linked to drug resistance in the treatment of AML with chemotherapeutic agents such as doxorubicin, daunorubicin, vincristine, mitoxantrone, and methotrexate (80)

Considering our findings, we hypothesise that a mechanism of rescue could be the reduction of the natural propensity for CBS to polymerise which could reduce one pathway towards aggregation (Fig