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Peer review Peer review information Nature Cancer thanks Sascha Dietrich, Alex Kentsis and Christopher Oakes for their contribution to the peer review of this work

Glutathione is used in biochemistry, molecular biology, toxicology, cellular physiology, and oxidative stress research

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

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Parent-Observed Clues: When Oxidative Stress May Be Part of the Pattern Fatigue that seems out of proportion to activity Slow or incomplete recovery after ordinary childhood illness Heat intolerance or unusual sensitivity to exertion Low muscle tone Sensory sensitivity that appears to worsen during illness or stress Behavior or regulation changes that track with fatigue or being unwell These are clues, not diagnostic signs