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Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism

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Emerging evidence suggests that a cocktail approach, that is, incorporating not only senolytics and senomorphics but also other therapeutic modalities, such as antioxidants, immune modulators, or metabolic enhancers may have a compounded effect in promoting healthy aging.261 Future clinical trials should explore these combination strategies, testing them in diverse age-related diseases to understand the potential for synergy and minimizing possible negative interactions between therapies