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Braaks hypothesis suggests that the -synuclein pathology begins in the ENS and then migrates to the brain, passing through the brainstem, midbrain, basal forebrain, and finally the cortical areas [118, 119]

These HED calculations are illustrative anchors for hypothesis generation only and are not clinical dosing recommendations

As structure models either obtained crystal structures or AlphaFold3 models were used 59
Therefore, the use of nano-DDS to exogenously supplement cancer cells with extra polyunsaturated fatty acids to exogenously regulate lipid peroxidation is also an effective strategy to improve the therapeutic effect of ferroptosis-driven cancer treatment [209,210,211]

10.1371/journal.pgen.0030162 PLoS Genet