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Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
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FIGURE 1 2.3.1 Release of inflammatory mediators and increased oxidative stress In the initial stages of periodontitis, bacterial metabolic products in dental plaque motivate host cells, resulting into the unleashing of various inflammatory mediators
These changes promote cell apoptosis and ultimately lead to the death of motor neurons, contributing to the onset of ALS (116)
A balanced discussion of current limitationscoupled with strategic calls for mechanistic and clinical researchis essential to advance this field
