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For plasma, these instances were observed at week 8 for free l-isoleucine, l-leucine, l-lysine, l-ornithine and l-valine, with levels of these amino acids being significantly higher in the test group compared with the control group (all P -values 0024 and maximum difference of 192 M) (online Supplementary Table 3a)

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F., Ghani A., Robson S

Brandes and co-workers identified a large E-loop of the enzyme as an essential structural feature for this process, involving specific cysteine and histidine residues within the loop