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The meta-analysis of these trials included thousands of patients

Notably, vitamin B12 plays a pivotal role in the health and maintenance of nerve cells, the formation of red blood cells, and the intricate process of DNA synthesis

Demirev PA, Hagan NS, Antoine MD, Lin JS, Feldman AB

[PubMed: 6305967] 16

In both studies, either DPSCs (experimental group) or saline (control group) was injected directly into the local periodontal bone defects immediately after deep cleaning, including scaling and root planning