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Although it remains challenging to obtain direct evidence, since most available tools, techniques, and model systems lack the resolution to clearly establish causality, many neurodegenerative diseases are strongly associated with energy failure, which ultimately contributes to neuronal death (discussed in more detail later)

J Neurosci Res 68:6575 Chen Y, Vartiainen NE, Ying W, Chan PH, Koistinaho J, Swanson RA (2001) Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism

By contrast, knocking out NF-B regulatory protein A20 in microglia was associated with massive microglia activation, neuroinflammation, and increased EAE pathology (44)

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This is characterized by the accumulation of low-density lipoprotein within the artery walls, leading to the formation of atheroma and distinct plaques consisting of proliferative fibrous tissue and calcifications (109, 110)