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8 Researchers also found that glucose metabolism starts decreasing up to 18 years (average, 14.1 years) before expected symptom onset, and brain atrophy up to 13 years (average, 4.7 years) before expected symptom onset
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Lin Y, Stephenson MC, Xin L, Napolitano A, Morris PG

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Chemical Name: L-tryptophyl-L-alanyl-glycyl-glycyl-L-alpha-aspartyl-L-alanyl-L-seryl-glycyl-L-glutamic acid