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Cold-chain handling: Lyophilized vials are stored at controlled temperatures and shipped in insulated packaging to maintain integrity

Recent studies have highlighted the role of mitochondrial impairment and altered energy metabolism as key contributors to the pathophysiology of GWS, with their severity correlating to disease progression in 19 veterans suffering from GWS and 17 healthy controls, comparing these factors to markers of peripheral inflammation (Golomb et al., Studies in GWS subjects have highlighted altered lipid homeostasis as a contributing factor to the abnormal accumulation of lipids, which in turn promotes cellular inflammation