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On the other hand, mitochondrial Ca 2 + efflux occurs via the Na + /Ca 2 + /Li + exchanger (NCLX) and Ca 2 + /H + exchanger (LETM1) on the inner membrane (Calvo-Rodriguez and Bacskai, 2021

Future research should prioritize: Mechanistic studies: Investigating how specific nutrient deficiencies affect neuronal excitability and elucidating the precise role of gut microbiota alterations in mediating neuroinflammatory processes

10.1016/j.molcel.2013.08.003 64 JiahuiW.XiangY.YouhuanZ.XiaominM.YuanzhuG.DejianZ.et al (2025)

These biomarkers could guide treatment decisions, helping clinicians select the most appropriate therapies for patients based on their individual senescence profiles.259 Developing Novel Delivery Systems: The efficacy of both senolytic and senomorphic therapies may be influenced by how these agents are delivered to target tissues