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Specifically, Lamina-Associated Domains, or LADs, are heterochromatic domains sequestered at the nuclear periphery heavily decorated by H3K9me2 (Poleshko et al., 2019)

136 observed that hyperactivation of mutant KRAS with the small molecule C1 leads to the activation of the PI3KAKT pathway, which enhances ROS generation (see below), leading to mitochondrial dysfunction, cell death and blockade of tumours with mutant KRAS

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