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[57] Approval of the original brand-name versions (such as Ozempic) was based on a biologic (recombinant DNA) production process using a genetically-modified yeast ( Saccharomyces cerevisiae ) to produce a precursor to semaglutide, and subsequent chemical processes (protein purification) to create the active ingredient

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10.1016/j.regpep.2012.12.007 7 BecejacT.CesarecV.DrmicD.HirslD.MadzaracG.DjakovicZ.et al (2018)

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