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The regulation of system X c /GSH/GPX4 axis in ferroptosis As the main antioxidant system against ferroptosis, the role of System X c /GSH/GPX4 axis is crucial in the treatment of various types of drug-resistant solid tumors, so an in-depth understanding of the regulatory mechanism of each node on this axis is of great significance for developing effective strategies for System X c /GSH/GPX4 axis targeted treatment of drug-resistant solid tumors (Figure 1)

Christ A, Lauterbach M, Latz E (2019) Western Diet and the Immune System: An Inflammatory Connection

The angiotensin IV analog Nle-Tyr-Leu-?-(CH2-NH2)3-4-His-Pro-Phe (Norleual) can act as a hepatocyte growth factor/c-Met inhibitor

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Since an intramolecular disulfide bond forms between the N- and C-terminal CRDs (Cys310-Cys629 and Cys303-Cys598), the higher amounts of reactive oxygen species cause Yap1 to undergo transitory redox-induced conformational changes that hide the NES