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This mutation leads to detrimental phenotypes such as premature aging, senescence, immune deficiency, and neurodegeneration 111,288

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While the implications for SARM1 in regulating axonal fate are well-established, the sensing mechanisms of this protein complex toward NAD + , NMN, or even possibly toward other NAD + metabolites are not fully understood, and may suggest that also the other NAD + metabolites could regulate more biological processes than initially thought 54

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