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Growth Factor Modulation The peptide has been shown to upregulate the expression of growth hormone receptors (GHR) in tendon fibroblasts

The results obtained in these studies suggest that MR expression is deleterious under pathological conditions, but not under normal physiology

doi: 10.1016/j.tig.2010.08.007 40 PetitMMongelliVFrangeulLBlancHJigginsFSalehMC

Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition

At a cellular mechanism, glutamate metabolism may be altered (Figure 4C), leading to excess gliotransmission
