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Estas modificaciones estructurales prolongan su actividad biolgica en comparacin con el IGF-1 nativo

It was observed that the upregulation of the Bcl-2 gene, which inhibits most types of apoptotic cells, and the downregulation of the Bax gene, which can promote apoptosis, were detected in cells treated with EGCG [88]

Hence, it is fair to hypothesize that both of the studied peptides bind allosterically to receptors, including acetylcholine ones, and alter their configuration, thus either fully preventing or substantially reducing the degree to which they bind to the modified form of beta-amyloid

Noctor et al., 2002