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Humans express three different catalytic subunit genes, PRKACA (protein kinase cAMP-activated catalytic subunit alpha), PRKACB (protein kinase cAMP-activated catalytic subunit beta), PRKACG (protein kinase cAMP-activated catalytic subunit gamma)

Neurological symptoms may take longer to resolveoften several weeks to monthsand improvement may be gradual rather than immediate

Second, the cross-sectional nature of the study limits our ability to establish causality and exclude the potential reverse causation between biomarkers and diseases, highlighting the need for larger interventional studies

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