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All these observations on different uremic toxins were confirmed by in vitro studies: RBCs from healthy subjects were treated with different concentrations of the uremic toxins and at different time points

Chronically high glucocorticoid levels induce neuronal atrophy and inhibit neurogenesis and synaptic plasticity in the hippocampus and prefrontal cortex, whereas excess IL-1 reduces BDNF production, collectively contributing to a depressed mood [306308]

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Villarreal-Soto S.A., Bouajila J., Pace M., Leech J., Cotter P.D., Souchard J.-P., Taillandier P., Beaufort S

doi: 10.1089/ars.2010.3221

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