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The shot delivers a high dose of therapeutic B12, usually in the form of cyanocobalamin or hydroxocobalamin

Reactive astrocytes in the context of PD increase production of ROS and decrease antioxidative protection, which may translate into neuronal damage

This approach is not widely used in adults, due to the high incidence of GVHD, transplant-related mortality and GR, but it may be used to treat children with class I/II -thalassemia safely, provided that ATG is given [100]

10.1007/s00395-020-0787-1 49 JinL.GengL.YingL.ShuL.YeK.YangR.et al (2022)

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