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537,547 ATF4 and its downstream target CHOP promote the expression of autophagy genes such as ATG5, ATG12, and BECN1, facilitating the clearance of unfolded proteins when the proteasome is overwhelmed

Mechanism: The neurotoxin works by blocking the release of acetylcholine, the neurotransmitter responsible for activating sweat glands

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Most recently, terameprocol reached phase I clinical trial for the treatment of high-grade glioma, still ongoing

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