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At the juxtaparanodes, contactin-2 interacts with Caspr2, and this association is necessary for clustering of voltage-gated potassium channels

pylori neutralizes the microenvironment, since the urease enzyme is also associated with the outer membrane of H

Hence, while the effects of novel inhibitors of methionine biosynthesis (sulfate reduction), or specific fungal methyltransferases, could be minimal in mammals, this could allow selective fungal inhibition

Beneficial effects are particularly noted in populations with baseline Zn deficiency, malabsorption, or chronic inflammation