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MMA is a myelin destabiliser and can affect normal myelin formation

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Recent evidence indicates that AD brains exhibit canonical ferroptotic pathology, which drives mitochondrial cardiolipin peroxidation, causes ultrastructural damage, impairs ATP synthesis, and ultimately triggers irreversible neurodegenerative decline ( Figure 3 ) (186)

This sustained activation amplifies cytokine production and exacerbates oxidative stress damage [15]

2 Oxidants also play an important role in driving the pro-resolution pathways of inflammation by stimulating the orderly removal of spent neutrophils (efferocytosis), and modulating key cysteine residues situated on several regulatory molecules of inflammation (Figure 1)