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10.1093/nar/gkw802 Nucleic Acids Res

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However, it has been proposed that GPER induces expression of ER36, a short isoform of the classical long isoform of ER, ER66 (23)

When iron is deficient, these processes are reversed, with the end result being a match between the levels of iron and PP 9, the two substrates for the final enzyme of heme biosynthesis, namely, ferrochelatase [FECH], thus minimizing excesses of toxic substrates in erythroblasts

However, the engine also needs other things to work properly such as oil and spark plugs