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The early activation of ion channels, kinase cascades, and PTMs indicates that stress signaling operates through a multilayered regulatory system capable of adjusting metabolism, gene expression, and protein stability within seconds to minutes of exposure

doi: 10.1016/j.ajpath.2011.11.003

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All mice are on a C57BL/6 background maintained in standard cages in a light- and temperature-controlled room and were allowed a standard chow diet and water ad libitum

One heme moiety is situated between the two transmembrane proteins of complex II, specifically SDHC and SDHD