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Some smaller peptides (e.g., collagen, GHKCu) can be taken orally or applied topically

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10.1016/j.mri.2019.12.009

Recently, it was reported that Propionibacterium acnes induces substance P and CGRP expression in the IVD and obvious LBP symptoms by stimulating NP cells to secrete the pro-algesic factor IL-8/CINC-1 through the TLR2-NF-B p65 pathway, which may provide a promising alternative therapeutic strategy for LBP patients in the clinic