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This bypasses the digestive system, where much of the potency of oral supplements can be lost, resulting in significantly higher bioavailability and therapeutic impact

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A study highlighted S100A1s ability to restore calcium cycling in cardiomyocytes, improving contractility in heart failure models, and gene therapy using AAV-S100A1 showed reduced fibrosis and hypertrophy in rodents (Rostami et al., 2025)