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[DOI] [PMC free article] [PubMed] [Google Scholar] 237.Paximada P., Echegoyen Y., Koutinas A.A., Mandala I.G., Lagaron J.M

195 Da Small Molecule 99% NNMT 5-Amino-1MQ is a selective small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that plays a key role in cellular energy metabolism and has been linked to obesity and metabolic dysfunction

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However, about 40% of patients developed motor fluctuations and dyskinesias after 4 to 6 years of treatment [1], demonstrating that further pharmacological research is needed in order to counterbalance side effects

Pharmacological inhibition of drug transporters in breast cancer cells did not affect the ability of GSH to rescue tumour growth in cystine-free conditions (Extended Data Fig