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doi: 10.3164/jcbn.13-53

The role of Nrf2 in liver fibrosis has been clarified by Lu, who showed that GCL subunits and GS are regulated byNrf2, which binds AREs present in their promoters [2] (Figure 6)

However, the possibility of IGF-I to influence neural stem cells (NSC) is still on debate despite the fact that IGF-I and IGF-IR are expressed in cultured NSC[60, 61], and that in response to IGF-I, cultured NSC proceed toward specific lineages, such as neurons[62] or oligodendrocytes[63]