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Therefore, metal toxicity (e.g., Ag, Cd, Cu, Hg) increases their concentrations in order to bind metals and subsequently sequester the ligand-metal complexes [55]

Financial support and sponsorship Efforts are supported by the Department of Defense Grants (W81XWH-18-1-0618, W81XWH-15-1-0558)

Understanding PK (pharmacokinetics) parameters in drug discovery is fundamental for the development of safe and effective drugs

Some patients choose optional lab work for optimization ($100-$200), but this isn't required

Nevertheless, the selection of patients who would benefit either from standard chemotherapy or venetoclax + azacitidine treatment in first-line therapy has yet to be established and the mechanisms of resistance still need to be discovered and overcome