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Experiments showed that VF-13 activated CB1, NPFF1, and NPFF2 receptors, as evidenced by ERK1/2 phosphorylation, inhibition of forskolin-induced cAMP accumulation, and neurite outgrowth in relevant cell lines (CHO, HEK-293, and Neuro 2A)
and genetic-obesity rodent models differ from human polygenic obesity
This study underscores that strength and aerobic exercise can positively influence immune system functioning and reduce fatigue during chemotherapy for cancer patients [163]

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The authors noted that well-designed, adequately powered clinical trials were lacking, and that definitive efficacy claims could not be supported by the existing literature at the time of publication
